Preclinical Studies

Mutated optic rod photoreceptors have been reprogrammed, using the gene-editing tool CRISPR/Cas9, reversing cellular degeneration and restoring visual function in two mouse models of retinitis pigmentosa. The study was done by researchers at University of California San Diego School of Medicine and Shiley Eye Institute at UC San Diego Health, with colleagues in China. Retinitis […]

Two new studies have uncovered socioeconomic disparities related to the health of patients with lupus. A study in Arthritis Rheumatology found a link between poverty and worse disease-associated medical complications over time, and a study in Arthritis Care Research discovered that the frequency of adverse pregnancy outcomes in Black and Hispanic patients with lupus is […]

The lungs of extremely premature lambs supported in a closed, sterile environment that enables fluid-based gas exchange grow and develop normally, researchers report. By Tracy Vence | April 25, 2017 … read more at: http://www.the-scientist.com/?articles.view/articleNo/49282/title/Artificial-Womb-Supports-Premature-Fetal-Lamb-Development/

A pile of cocaine hydrochloride. Credit: DEA Drug Enforcement Agency, public domain Researchers at the Medical University of South Carolina (MUSC) have used viruses to infect neurons with genes that allow them to switch on brain receptors involved in suppressing addiction relapse. Results of these preclinical studies were published in the September 28th, 2016 issue […]

Glioblastoma (histology slide). Credit: Wikipedia/CC BY-SA 3.0 Investigational “hunter” immune cells engineered to seek out and attack a deadly brain cancer known as glioblastoma (GBM) infiltrated patients’ tumors and triggered thousands of more T cells once inside, researchers from Penn Medicine reported in a late breaking abstract at the AACR Annual Meeting 2017 (Abstract LB-053). […]

A well-known rheumatoid arthritis medication containing the active agent adalimumab, a therapeutic human monoclonal antibody, is also effective for treating non-infectious uveitis, a rare eye disease. This has now been discovered … … read more at: https://medicalxpress.com/news/2017-03-tocilizumab-uveitis-juvenile-idiopathic-arthritis.html

The largest CBD study presented efficacy and safety data on GW Pharmaceutical’s investigational medicine, Epidiolex (cannabidiol) from open-label Expanded Access programs at 16 sites. The study (abstract 3.034) involves 261 people, predominantly children, who have severe epilepsy that had not responded adequately to other treatments. The average age of the participants was 11. Over the […]