Preclinical Studies

The stock of InVivo Therapeutics Holdings Corp. (NASDAQ:NVIV) hit a new 52-week low and has $1.33 target or 6.00% below today’s $1.42 share price. The 6 months bearish chart indicates high risk for the $13.77 million company. The 1-year low was reported on Feb, 18 by Barchart.com. If the $1.33 price target is reached, the […]

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Oct. 17 (UPI) — By combining antibiotics and probiotics, researchers have developed a one-two punch to eradicate two strains of drug-resistant bacteria that often infect wounds, according to a preclinical study. MIT researchers encapsulated probiotic bacteria in a protective shell of alginate, which is a biocompatible material that prevents the probiotics from being killed by […]

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The discovery of CHD2’s role in epilepsy offers new diagnostic tools for families and clinicians of children with Dravet syndrome and related genetic epilepsies. In addition, the creation of a zebrafish model for CHD2 encephalopathy may facilitate the discovery of new drugs that can treat patients with this form of epilepsy. Dravet syndrome is a […]

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The first of three studies (Platform Session A.04) presents a culmination of 20-30 years of research that sought out to understand if intellectual disability (ID) predicts a low chance of remission and a high risk of intractability in epilepsy. Researchers of this study focused on examining the severity of ID to predict epilepsy outcome. A […]

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A recent study, published in the journal Cell Reports, characterizes these silent seizures in a mouse model of Dravet syndrome and identifies the brain area that could be targeted to stop them. “We were able to pinpoint the exact spot in the brain that causes the seizures,” said Jeanne Paz, PhD, the senior author of […]

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The term “epilepsy” covers a spectrum of brain disorders with symptoms ranging from mildly odd sensations to seizures, loss of consciousness and death. Worldwide, the condition affects 50 million people, according to the World Health Organization. Current treatments work in only about 70 percent of those who try them. To identify some new options, Marcel […]

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The Johns Hopkins investigators say the findings suggest that if physicians are on the lookout for these potentially reversible conditions and treat them aggressively at the first sign of trouble, patients are more likely to survive. “The factors most associated with death in these patients are things that we know how to treat,” says Arun […]

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“It was no way to live,” she said. Loyola epileptologist Jorge Asconapé, MD, recommended surgery to remove scar tissue in her brain that was triggering the seizures. Neurosurgeon Douglas Anderson, MD, performed the surgery, called an amygdalohippocampectomy. Ms. Fleck hasn’t had a single seizure in the more than three years since her surgery. “I’ve got […]

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The SCN8A gene mediates electrical signaling in the brain by controlling the flow of sodium currents. Findings from these studies could inform the development of precision medicine therapeutics and lead to more effective strategies for diagnosing and treating patients with epilepsy. In the first study, (abstract 3.142) researchers from the University of Michigan describe how […]

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The research was presented at Neuroscience 2010, the annual meeting of the Society for Neuroscience, held in San Diego. Senior author Lir-Wan Fan, PhD, of the University of Mississippi Medical Center, and her colleagues previously showed that adult rats exposed to lipopolysaccharide, a toxin produced by certain bacteria that triggers a strong inflammatory immune response, […]

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A recent review article in the European journal Seizure, by researchers at University of Cincinnati Epilepsy Center at the UC Gardner Neuroscience Institute, looks at the stress-seizure relationship and how adopting stress reduction techniques may provide benefit as a low risk form of treatment. The relationship between stress and seizures has been well documented over […]

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The abstracts describe results from the first 51 subjects enrolled in the studies. Among other findings, the researchers report that approximately 50 percent of the subjects responded to the CBD oil therapy with overall sustained improvement in seizure control over a six-month period. Seizures declined between 32 and 45 percent in the responders, depending on […]

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The study involved 70 people who participated in a 16-week treatment program for cocaine addiction. Thirty-five received counseling and baclofen, and 35 received counseling and a placebo. Cocaine use was monitored by thriceweekly urine tests. Analyses showed that people who received the counseling/baclofen combination had lower levels of drug use during the treatment period than […]

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The study, published today (Sunday 30 December) in the journal Addiction by researchers from the University of Bath and King’s College London, draws on data collected from across 28 EU Member states, as well as Norway and Turkey by the European Monitoring Centre for Drugs and Drug Addiction. The findings show that for herbal cannabis, […]

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The discovery, published online in PLoS Genetics, means some infants with Dravet syndrome, a type of epilepsy that often begins with fever-induced (febrile) seizures, would benefit from genetic testing to identify whether they have a mutation in the SCN9A gene, which the researchers found causes seizures by affecting sodium channels in the brain. Infants who […]

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