Cannabidiol’s Anti-Seizure Activity Depends on the Type of Neurons

The anti-seizure effect of cannabidiol in Dravet syndrome is dependent on the type of neurons upon which it acts, but not on the activity of sodium channels, a study finds.

The findings of the study, “Investigating the Therapeutic Mechanism of Cannabidiol in a Human Induced Pluripotent Stem Call (iPSC)-Based Cellular Model of Dravet Syndrome,” were published in Cold Spring Harbor Symposia on Quantitative Biology.

Dravet syndrome is a severe type of drug-resistant epilepsy that usually emerges during an infant’s first year of life and is characterized by seizures, cognitive deficits, and increased mortality. Most patients carry genetic mutations in the SCN1A gene, which encodes for a sub-unit of a sodium channel essential for the generation and transmission of electrical signals in the brain.

Recently, new treatments with the potential to control epileptic seizures associated with Dravet syndrome have begun to emerge.

Cannabidiol (CBD),

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