Simvastatin for SPMS

Simvastatin is an approved statin commonly used to lower cholesterol that is currently being studied as a potential treatment to slow the progression of multiple sclerosis (MS).

How simvastatin works

MS symptoms are caused when the immune system mistakenly targets the myelin sheath, a protective layer surrounding nerve fibers in the brain and spinal cord. This causes inflammation and damage to the myelin, disrupting nerve signaling.

Statins have been shown to potentially have anti-inflammatory and neuroprotective properties. Exactly how the drug alters the immune system is not clearly understood, but researchers have developed several theories. For example, statins may interact with T-cells, a type of immune cell, by preventing them from becoming active or by stopping them from entering the brain and spinal cord.

There is evidence suggesting that simvastatin can inhibit the release of pro-inflammatory cytokines (a small secreted protein

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