A study involving two patients has demonstrated the effects of botulinum toxin in improving the appearance of a facial abnormality known as scleroderma en coup de sabre, which is sometimes seen in linear scleroderma.
Localized scleroderma is a form of scleroderma that affects only the skin. Linear scleroderma is a rare form of localized scleroderma characterized by skin and subcutaneous tissue abnormalities found on one side of the body.
Sometimes patients have a facial abnormality called en coup de sabre, or ECDS, a thickening of skin across the face that may look like a sword cut and usually extends from the forehead into the frontal scalp.
Previous studies have shown that the use of the chemotherapeutic agent methotrexate and intravenous corticosteroids can be effective in treating ECDS. But these methods aren’t always successful.
More recently, a study has demonstrated the effectiveness of the toxin produced by the bacterium Clostridium botulinum, botulinum toxin (BTX),