The long-term administration of cannabis-plant derived extracts containing a 50 to 1 ratio of CBD to THC is safe and effective in children with treatment-resistant epilepsy, according to clinical trial data published in the journal Annals of Clinical and Translational Neurology.
Canadian researchers assessed the adjunctive use of a proprietary CBD/THC extract (aka TIL-TC150, manufactured by Tilray Inc.) over a 20-week period in children with Dravet syndrome. Investigators reported that the treatment was “safe and well tolerated,” and was associated with reduced seizure frequency and improvements in quality of life measures.
They concluded: “To our knowledge, this study is the first of its kind to examine with rigor the dosing and tolerability of a mixed cannabinoid product containing both CBD and THC in children with DRE (drug-resistant epilepsy). … Our study adds to a growing body of evidence that cannabinoids exert