Dextroamphetamine Plus Physical Therapy Nonsuperior to Placebo for Improving Post-Stroke Motor Recovery

Physical therapy plus dextroamphetamine, an amphetamine enantiomer and stimulant of the central nervous system, is not associated with 3-month improvements in motor function recovery compared with placebo plus physical therapy in patients with hemispheric ischemic stroke, according to study findings published in JAMA Neurology.

Patients with cortical or subcortical ischemic stroke and moderate or severe motor deficits were enrolled in the study. Researchers randomly assigned participants to receive either 10 mg dextroamphetamine (n=32) or placebo (n=32). Both interventions were combined with a 1-hour physical therapy session 1 hour after administration of the treatment drug or placebo. Therapy sessions occurred every 4 days for a total of 6 sessions.

At 3 months post-stroke, the investigators compared the 2 groups with regard to the change in Fugl-Meyer motor scores from baseline. Additional secondary measures included changes in the Action Research Arm Test, Ambulation Speed and Distance, Beck Depression Inventory, Canadian Neurological

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