Dietary supplementation with ketone esters significantly decreased the frequency of seizures and improved behavior, learning, memory, and overall function in a recent mouse study of Angelman syndrome.
The study, “Ketone ester supplementation attenuates seizure activity, and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model,” was published in the journal Neurobiology of Disease.
Seizures are common in Angelman patients, with approximately 80 percent of all these patients being diagnosed with epilepsy.
The availability of effective anti-epileptic medications is limited, and the medications that do exist are known to have side effects that can alter cognition.
Dietary therapies have been seen to help overcome epilepsy in animal studies. The ketogenic diet — a high-fat, low-carbohydrate, moderate-protein diet — has been shown to be well-tolerated and successful in some Angelman patients. This diet is thought to be beneficial as it results in higher levels of blood ketones, which are