Potential risk factors for epilepsy in survivors of acute symptomatic neonatal seizure include preterm birth, brain injury, and having antiseizure medications prescribed at discharge following the seizure, according to study findings published in Pediatric Neurology. Despite the findings, adjustment for relevant confounders revealed that these risk factors may be weak predictors of epilepsy in those who survive a neonatal seizure.
Using a database from the Neonatal Neurocritical Care Service at a university hospital in San Francisco, researchers identified neonates with acute symptomatic seizures who were admitted to the neonatal care unit between 2008 and 2014. The researchers sought to identify risk factors for seizures in this population by reviewing hospital records. Specifically, the investigators reviewed demographic data, magnetic resonance imaging (MRI) results, seizure etiology, results on continuous video electroencephalogram, and use of antiseizure medications.
Of the 144 children who met inclusion criteria, 87 patients with ≥1-year follow-up data available for