George E. Anastassov, MD, CEO of AXIM Biotech, told us the main rationale behind using chewing gum as the delivery system for Cannabidiol (CBD) is that “the oral-pharyngeal mucosa offers extensive territory for rapid and controlled absorption of the API and the avoidance of first pass metabolism.”
“Within 20 minutes, the oral mucosa absorbs 80 to 90 percent of the active ingredient and bypasses the gut and liver metabolism,” added Anastassov. “Chewing gum is also a socially acceptable delivery system of the API compared to smoking and other systems.”
Additionally, Anastassov explained mastication is believed to improve cerebral circulation, increase the intestinal motility, enhance memory coordination, and decrease stress.
“The combination of CBD and chewing should have a cumulative effect,” he said.
Ph II clinical trials