Cannabidiol benefits and mechanisms shown in mouse study of Dravet syndrome

Treatment with cannabidiol reduces some major symptoms in mice with a genetic condition recapitulating Dravet syndrome, a devastating childhood brain disorder.

Cannabidiol is a non-intoxicating substance among the several active compounds derived from Cannabis plants. This molecule can also be produced synthetically.

The results of its use to treat Dravet syndrome are reported in the latest edition of the Proceedings of the National Academy of Sciences, PNAS.

Children with this syndrome have severe, difficult-to-control epilepsy. Their seizures, which can be frequent and prolonged, first appear in infancy. As the affected individual grows, intellectual impairments, autism-like behaviors and other debilitating problems can emerge.

Many patients need nearly constant care. Some are at risk for early death. Few therapeutic options exist for this life-long condition.

UW Medicine researcher William Catterall, one of the authors of the PNAS paper, noted, “There has been increasing interest in the lay

... read more at: https://www.eurekalert.org/pub_releases/2017-10/uowh-cba100917.php

by