Designer brain receptors used in preclinical study to suppress cued cocaine seeking


cocaine
A pile of cocaine hydrochloride. Credit: DEA Drug Enforcement Agency, public domain

Researchers at the Medical University of South Carolina (MUSC) have used viruses to infect neurons with genes that allow them to switch on brain receptors involved in suppressing addiction relapse. Results of these preclinical studies were published in the September 28th, 2016 issue of the Journal of Neuroscience. The technology, called designer receptors exclusively activated by designer drugs, or DREADDs, is one of the most promising gene therapies for the future

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